Liverpool COVID-19 Interactions

Potential Interaction

_Atazanavir alone (old primary)

Trazodone

Quality of Evidence: Very Low

Summary:

Coadministration has not been studied. Trazodone is primarily metabolized by CYP3A4. Atazanavir could potentially increase trazodone concentrations. Use with caution and consider a lower dose of trazodone. Note, the product label for atazanavir advises caution when prescribing atazanavir with medicinal products which have the potential to increase the QT interval; trazodone has a conditional risk of QT prolongation and/or TdP on the CredibleMeds.org website.

Description:

Particular caution should be used when prescribing atazanavir in association with medicinal products which have the potential to increase the QT interval.

Reyataz Summary of Product Characteristics, Bristol-Myers Squibb Pharmaceuticals Ltd, October 2018.

Concomitant use of trazodone and Reyataz with or without ritonavir is expected to increase plasma concentrations of trazodone. Nausea, dizziness, hypotension, and syncope have been observed following coadministration of trazodone and ritonavir. If trazodone is used with a CYP3A4 inhibitor such as Reyataz, the combination should be used with caution and a lower dose of trazodone should be considered.

Reyataz US Prescribing Information, Bristol-Myers Squibb Company, March 2018.