Academic Sponsors / Collaborators
Interaction Checker
We have produced various materials in PDF format to aid the use of experimental agents in the treatment of COVID-19.
These resources are freely available and the Liverpool Drug Interactions Group would like to encourage the dissemination (with an appropriate acknowledgement) of this drug-drug interaction information for non-commercial use. If referencing these Prescribing Resources, it is important to include the publication date since these resources are updated as new data come to light. Please cite as: [Prescribing Resource Title], [PDF Publication Date], University of Liverpool, available from www.covid19-druginteractions.org, [accession date].
UPDATED - Bebtelovimab added.
This document explains how we have evaluated the drug-drug interaction risk of the COVID-19 therapies (licensed and under clinical investigation) and gives details of their metabolism, interaction potential and cardiac effects.
Updated 13 April 2022
NEW
This flow chart shows how a patient may be assessed when considering treatment with Paxlovid (nirmatrelvir/ritonavir).
Updated 10 March 2022
NEW
This document was developed for use in resource-limited settings where internet access is not always available and was designed to allow users see at-a-glance the risk and management of drug-drug interactions between Paxlovid and selected drugs from the WHO Essential Medicines list.
Updated 08 March 2022
This document gives details of the duration of the CYP3A4 inhibitory effect of ritonavir and guidance as to how to manage comedications that may have been paused or dose-adjusted during treatment with Paxlovid (nirmatrelvir/ritonavir).
Updated 19 May 2022
UPDATED - interactions with new comedications added.
Details of the nature of drug interactions with key COVID-19 therapies and many comedication classes are given in this PDF.
Updated 25 April 2022
UPDATED - interactions with new comedications added.
A summary of interactions with COVID-19 antiviral therapies (licensed or under clinical investigation) and over 600 comedications are given in this PDF.
Updated 25 April 2022
UPDATED - interactions with new comedications added.
A summary of interactions with COVID-19 host-directed therapies (licensed or under clinical investigation) and over 600 comedications are given in this PDF.
Updated 25 April 2022
UPDATED - Bebtelovimab added.
Advice for administering COVID-19 therapies (licensed or under clinical investigation) to patients who cannot swallow is given in this PDF.
Updated 13 April 2022
UPDATED - Nirmatrelvir/ritonavir (Paxlovid) and tixagevimab/cilgavimab (Evusheld) added.
Details of dose modifications for COVID-19 therapies (licensed or under clinical investigation) which may be required for patients with renal impairment are given in this PDF.
Updated 18 March 2022
UPDATED - Nirmatrelvir/ritonavir (Paxlovid) and tixagevimab/cilgavimab (Evusheld) added.
Details of dose modifications for COVID-19 therapies (licensed or under clinical investigation) which may be required for patients with hepatic impairment are given in this PDF.
Updated 18 March 2022
